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HIF-2α agonist 2

CAS No. 2750141-15-0

HIF-2α agonist 2( —— )

Catalog No. M36012 CAS No. 2750141-15-0

HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structure of HIF-2a-ARNT complex without cytotoxicity to 786-o-Reha-Luc cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    HIF-2α agonist 2
  • Note
    Research use only, not for human use.
  • Brief Description
    HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structure of HIF-2a-ARNT complex without cytotoxicity to 786-o-Reha-Luc cells.
  • Description
    HIF-2α agonist 2 (compound 10) is a HIF-2α agonist with an EC50 value of 1.68 μM at the dose of 20 μM. HIF-2α agonist 2 is non-cytotoxic against 786-O-HRE-Luc cells. HIF-2α agonist 2 can be used for oxygen metabolism research.
  • In Vitro
    Cell Viability Assay Cell Line:786-O-HRE-Luc cell line Concentration:0.003-20 μM Incubation Time:24 hours Result:Showed no cytotoxicity to 786-O-Luc cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    HIF/HIF Prolyl-hydroxylase
  • Recptor
    HIF | HIF/HIF Prolyl-Hydroxylase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2750141-15-0
  • Formula Weight
    416.09
  • Molecular Formula
    C13H8Br2N2O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (240.33 mM; Ultrasonic (<60°C)
  • SMILES
    N(C=1C=2C(S(=O)(=O)N1)=CC=CC2)C3=CC(Br)=CC(Br)=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yu Y, et al. Insight into the binding mode of HIF-2 agonists through molecular dynamic simulations and biological validation. Eur J Med Chem. 2021 Feb 5;211:112999.?
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