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Fuzapladib
CAS No. 141283-87-6
Fuzapladib( —— )
Catalog No. M35957 CAS No. 141283-87-6
Fuzapladib (IS-741) (IS-741) is a phospholipase A2 inhibitor that can inhibits the expression of Mac-1, a cell adhesion molecule.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 186 | In Stock |
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| 5MG | 141 | In Stock |
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| 10MG | 212 | In Stock |
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| 25MG | 448 | In Stock |
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| 50MG | 639 | In Stock |
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| 100MG | 830 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameFuzapladib
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NoteResearch use only, not for human use.
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Brief DescriptionFuzapladib (IS-741) (IS-741) is a phospholipase A2 inhibitor that can inhibits the expression of Mac-1, a cell adhesion molecule.
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DescriptionFuzapladib (IS-741), an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site.
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In Vitro——
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In VivoAnimal Model:RatsDosage:50 mg/kg Administration:P.o.; for 7 days Result:Significantly reduced myeloperoxidase (MPO) activity and mucosal IL-8 levels in rat ileum, reduced polymorphonuclear cells and Mac-1 positivity Infiltration of cells into inflammatory lesions, effectively alleviated trinitrobenzenesulfonic acid (TNBS)-induced ileitis.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPhospholipase
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RecptorPhospholipase
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Research Area——
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Indication——
Chemical Information
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CAS Number141283-87-6
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Formula Weight379.4
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Molecular FormulaC15H20F3N3O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (263.57 mM; Ultrasonic )
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SMILESN(C(=O)C1CCCCC1)C2=C(NS(CC)(=O)=O)N=CC(C(F)(F)F)=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Efipladib
Efipladib (PLA 902) is a potent, selective and orally active inhibitor of cPLA2α with IC50 of 20 nM for LTB4 inhibition.
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CCT129957
CCT129957 is a novel and potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of about 3 μM and a GC50 of 15 μM.CCT129957 exhibits anticancer activity and inhibits Ca2+ release in squamous cells.
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Melittin TFA(20449-7...
Melittin TFA is a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecular weight PLA2.Melittin, an immunologically related PLA2 stimulating peptide from bee venom, increases the activity of the high molecular weight enzyme.
