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TDI-10229

CAS No. 2810887-45-5

TDI-10229( —— )

Catalog No. M35801 CAS No. 2810887-45-5

TDI-10229 is a potent and orally available inhibitor of soluble adenylyl cyclase (sAC, ADCY10), displaying nanomolar inhibition of sAC in both biochemical and cellular assays (IC50 = 195 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TDI-10229
  • Note
    Research use only, not for human use.
  • Brief Description
    TDI-10229 is a potent and orally available inhibitor of soluble adenylyl cyclase (sAC, ADCY10), displaying nanomolar inhibition of sAC in both biochemical and cellular assays (IC50 = 195 nM).
  • Description
    TDI-10229 is a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC50 of 195 nM) and exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound.
  • In Vitro
    ——
  • In Vivo
    Animal Model:MouseDosage:20 mg/kg Administration:P.o.(Pharmacokinetic Analysis)Result:The Cmax, AUC and MRT were 15.5 μM, 94 μg h/mL and 3.95 hours, respectively.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    cAMP
  • Recptor
    cAMP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2810887-45-5
  • Formula Weight
    313.78
  • Molecular Formula
    C16H16ClN5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (398.37 mM; Ultrasonic )
  • SMILES
    Cc1c(Cc2ccccc2)c(nn1C)-c1cc(Cl)nc(N)n1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Balbach M, et al. Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization [published online ahead of print, 2021 Aug 31]. Mol Hum Reprod. 2021;gaab054.?
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