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TDI-10229
CAS No. 2810887-45-5
TDI-10229( —— )
Catalog No. M35801 CAS No. 2810887-45-5
TDI-10229 is a potent and orally available inhibitor of soluble adenylyl cyclase (sAC, ADCY10), displaying nanomolar inhibition of sAC in both biochemical and cellular assays (IC50 = 195 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 177 | In Stock |
|
| 5MG | 160 | In Stock |
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| 10MG | 236 | In Stock |
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| 25MG | 432 | In Stock |
|
| 50MG | 635 | In Stock |
|
| 100MG | 918 | In Stock |
|
| 200MG | 1237 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTDI-10229
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NoteResearch use only, not for human use.
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Brief DescriptionTDI-10229 is a potent and orally available inhibitor of soluble adenylyl cyclase (sAC, ADCY10), displaying nanomolar inhibition of sAC in both biochemical and cellular assays (IC50 = 195 nM).
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DescriptionTDI-10229 is a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC50 of 195 nM) and exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound.
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In Vitro——
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In VivoAnimal Model:MouseDosage:20 mg/kg Administration:P.o.(Pharmacokinetic Analysis)Result:The Cmax, AUC and MRT were 15.5 μM, 94 μg h/mL and 3.95 hours, respectively.
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Synonyms——
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PathwayGPCR/G Protein
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TargetcAMP
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RecptorcAMP
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Research Area——
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Indication——
Chemical Information
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CAS Number2810887-45-5
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Formula Weight313.78
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Molecular FormulaC16H16ClN5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (398.37 mM; Ultrasonic )
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SMILESCc1c(Cc2ccccc2)c(nn1C)-c1cc(Cl)nc(N)n1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Balbach M, et al. Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization [published online ahead of print, 2021 Aug 31]. Mol Hum Reprod. 2021;gaab054.?
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