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CB1R Allosteric modulator 3
CAS No. 2633686-36-7
CB1R Allosteric modulator 3( —— )
Catalog No. M35571 CAS No. 2633686-36-7
CB1R Allosteric modulator 3 is a potent CB1R modulator that inhibits cAMP and β-Arrestin and can be used for the study of obesity and nicotine addiction.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 53 | Get Quote |
|
| 5MG | 77 | Get Quote |
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| 10MG | 132 | Get Quote |
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| 25MG | 214 | Get Quote |
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| 50MG | 319 | Get Quote |
|
| 100MG | 464 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCB1R Allosteric modulator 3
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NoteResearch use only, not for human use.
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Brief DescriptionCB1R Allosteric modulator 3 is a potent CB1R modulator that inhibits cAMP and β-Arrestin and can be used for the study of obesity and nicotine addiction.
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DescriptionCB1R Allosteric modulator 3 is a CB1R positive allosteric modulator. CB1R Allosteric modulator 3 has potent inhibition of cAMP and β-Arrestin with EC50 values of 0.018 μM and 1.241 μM, respectively.
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In VitroCB1R Allosteric modulator 3 (compound 44) (0.10 nM-10 μM, 30 min) has potent inhibition of cAMP and β-Arrestin with EC50 values of 0.018 μM and 1.241 μM, respectively.CB1R Allosteric modulator 3 can enhance CB1R ago-PAM activity because of small lipophilic functional groups on the ortho-position of the GAT211 site-III phenyl ring.
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetcAMP
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RecptorcAMP | Cannabinoid Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number2633686-36-7
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Formula Weight376.84
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Molecular FormulaC22H17ClN2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (265.36 mM; Ultrasonic )
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SMILESC(CN(=O)=O)(C1=C(NC=2C1=CC=CC2)C3=CC=CC=C3)C4=C(Cl)C=CC=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Peter C Schaffer, et al. Focused structure-activity relationship profiling around the 2-phenylindole scaffold of a cannabinoid type-1 receptor agonist-positive allosteric modulator: site-III aromatic-ring congeners with enhanced activity and solubility. Bioorg Med Chem. 2020 Nov 1;28(21):115727. ?
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