0990CL( —— )

Catalog No. M33243 CAS No. 511514-03-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

0990CL
Note

Research use only, not for human use.
Brief Description

0990CL is an effective heterotrimer Gαi subunit specific inhibitor, which can interact with purified Go± in GDP-bound state, and can block α2AR mediated cAMP regulation.
Description

0990CL is a specific heterotrimeric Gαi subunit inhibitor by direct interaction with Gαi. 0990CL is able to block α2AR mediated regulation of cAMP.
In Vitro

0990CL?(100 nM-1 μM; 24 hours) is able to restore α2AR/Gαi?mediated cAMP levels elicited by Fsk and UK14304 in HEK293 GloSensor cells. When the dosage is at 100 nM, it restores 31% of the reduction of cAMP.0990CL?(30 μM; pre-treatment 30mins) shows selectivity for Gαi1 over Gαq. It demonstrates selectivity for Gαi?and Gαq and results in a maximum endpoint fluorescence reduction of 38±8% and 10%, respectively.
In Vivo

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Synonyms

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Pathway

GPCR/G Protein
Target

cAMP
Recptor

cAMP
Research Area

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Indication

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1. Appleton KM,et al. Development of inhibitors of heterotrimeric Gαi subunits.Bioorg Med Chem. 2014 Jul 1;22(13):3423-34.?

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