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I942

CAS No. 868145-09-9

I942( —— )

Catalog No. M33988 CAS No. 868145-09-9

I942 is a novel, selective ACyclic nucleotide (NCN) EPAC1 agonist that activates exchange proteins to regulate inflammatory gene expression in human umbilical blood tubes and inhibit pro-inflammatory cytokine signaling associated with cardiovascular disease.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 227 In Stock
10MG 370 In Stock
25MG 606 In Stock
50MG 820 In Stock
100MG 1107 In Stock
200MG Get Quote In Stock
500MG 2260 In Stock
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Biological Information

  • Product Name
    I942
  • Note
    Research use only, not for human use.
  • Brief Description
    I942 is a novel, selective ACyclic nucleotide (NCN) EPAC1 agonist that activates exchange proteins to regulate inflammatory gene expression in human umbilical blood tubes and inhibit pro-inflammatory cytokine signaling associated with cardiovascular disease.
  • Description
    I942 is a first in class, selective non-cyclic nucleotide (NCN) EPAC1 agonist. I942 can attenuate proinflammatory cytokine signalling normally associated with cardiovascular diseases.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    cAMP
  • Recptor
    cAMP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    868145-09-9
  • Formula Weight
    369.43
  • Molecular Formula
    C20H19NO4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (676.72 mM; Ultrasonic )
  • SMILES
    O(CC(NS(=O)(=O)C1=C(C)C=C(C)C=C1)=O)C2=CC3=C(C=C2)C=CC=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Graeme Barker, et al. The Potential of a Novel Class of EPAC-Selective Agonists to Combat Cardiovascular Inflammation. J Cardiovasc Dev Dis. 2017 Dec 5;4(4):22.?
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