γ-Secretase modulator 13( —— )

Catalog No. M35626 CAS No. 1353570-40-7

γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that inhibits the production of amyloid β-peptide Aβ42 and can be used to study Alzheimer's disease and tumors.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

γ-Secretase modulator 13
Note

Research use only, not for human use.
Brief Description

γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that inhibits the production of amyloid β-peptide Aβ42 and can be used to study Alzheimer's disease and tumors.
Description

γ-Secretase modulator 13 (compound 4) is a gamma-secretase modulator (GSMs) that inhibits the production of the aggregated amyloid β-peptide Aβ42 with an IC50 value of 163 nM. γ-Secretase modulator 13 can be used in the study of Alzheimer's disease.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Neuroscience
Target

Gamma-secretase
Recptor

Gamma-secretase
Research Area

——
Indication

——

Chemical Information

CAS Number

1353570-40-7
Formula Weight

422.52
Molecular Formula

C22H23FN6S
Purity

>98% (HPLC)
Solubility

——
SMILES

FC=1C=C(C=CC1N2C=NC(=C2)C)C=3N=C(SC3)NC4=C5C(=NN4CC)CCCC5
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Kevin D Rynearson, et al. Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators. Bioorg Med Chem. 2020 Nov 15;28(22):115734.?

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