DHFR-IN-4

Research use only, not for human use.

DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with anti-tumor activity, which also inhibits EGFR and HER2, and is useful for studying pancreatic cancer.

DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with an IC50 value of 123 nM. DHFR-IN-4 also has inhibitory activity against EGFR and HER2 with IC50s of 246 nM and 357 nM, respectively. DHFR-IN-4 has remarkable broad spectrum cytotoxic potency against cancer cells.

DHFR-IN-4 (compound 42) (0-100 μM; 72 h) shows remarkable broad spectrum cytotoxic potency against HepG2, MCF-7, HCT-116, PC3 and HeLa.Cell Cytotoxicity Assay Cell Line:HepG2, MCF-7, HCT-116, PC3 and HeLa Concentration:0-100 μM Incubation Time:72 h Result:Exhibited antiproliferative activity against HepG2, MCF-7, HCT-116, PC3 and HeLa with IC50s of 9.67±0.7 μM, 8.46±0.7 μM, 13.24±0.9 μM, 11.17±1.0 μM and 6.90±0.5 μM.

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Cell Cycle/DNA Damage

DHFR

DHFR

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2820126-49-4

371.46

C18H21N5O2S

>98% (HPLC)

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O=C(NN)C1=CSC2=NC(=C(C=3C=CC(=CC3)C)N21)CN4CCOCC4

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(-20℃)

With Ice Pack

≥ 2 years