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DHFR-IN-4

CAS No. 2820126-49-4

DHFR-IN-4( —— )

Catalog No. M35563 CAS No. 2820126-49-4

DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with anti-tumor activity, which also inhibits EGFR and HER2, and is useful for studying pancreatic cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DHFR-IN-4
  • Note
    Research use only, not for human use.
  • Brief Description
    DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with anti-tumor activity, which also inhibits EGFR and HER2, and is useful for studying pancreatic cancer.
  • Description
    DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with an IC50 value of 123 nM. DHFR-IN-4 also has inhibitory activity against EGFR and HER2 with IC50s of 246 nM and 357 nM, respectively. DHFR-IN-4 has remarkable broad spectrum cytotoxic potency against cancer cells.
  • In Vitro
    DHFR-IN-4 (compound 42) (0-100 μM; 72 h) shows remarkable broad spectrum cytotoxic potency against HepG2, MCF-7, HCT-116, PC3 and HeLa.Cell Cytotoxicity Assay Cell Line:HepG2, MCF-7, HCT-116, PC3 and HeLa Concentration:0-100 μM Incubation Time:72 h Result:Exhibited antiproliferative activity against HepG2, MCF-7, HCT-116, PC3 and HeLa with IC50s of 9.67±0.7 μM, 8.46±0.7 μM, 13.24±0.9 μM, 11.17±1.0 μM and 6.90±0.5 μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DHFR
  • Recptor
    DHFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2820126-49-4
  • Formula Weight
    371.46
  • Molecular Formula
    C18H21N5O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NN)C1=CSC2=NC(=C(C=3C=CC(=CC3)C)N21)CN4CCOCC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sabry MA, et al. New thiazole-based derivatives as EGFR/HER2 and DHFR inhibitors: Synthesis, molecular modeling simulations and anticancer activity. Eur J Med Chem. 2022 Aug 10;241:114661.?
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