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DS44960156

CAS No. 2361327-08-2

DS44960156( —— )

Catalog No. M34971 CAS No. 2361327-08-2

DS44960156 is a novel selective inhibitor of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) that inhibits both MTHFD2 and MTHFD1 and can be used in cancer research.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 179 In Stock
5MG 163 In Stock
10MG 250 In Stock
25MG 432 In Stock
50MG 616 In Stock
100MG 886 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    DS44960156
  • Note
    Research use only, not for human use.
  • Brief Description
    DS44960156 is a novel selective inhibitor of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) that inhibits both MTHFD2 and MTHFD1 and can be used in cancer research.
  • Description
    DS44960156 is a selective Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor, with IC50 values of 1.6 μM and >30 μM for MTHFD2 and MTHFD1, respectively.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DHFR
  • Recptor
    DHFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2361327-08-2
  • Formula Weight
    349.34
  • Molecular Formula
    C20H15NO5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (286.25 mM; Ultrasonic )
  • SMILES
    OC(=O)c1ccc(cc1)C(=O)N1CCc2c(C1)c(=O)oc1ccccc21
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Junya Kawai, et al. Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold. ACS Med Chem Lett. 2019 May 24;10(6):893-898.?
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