Molnupiravir

Research use only, not for human use.

Molnupiravir (EIDD-2801) is an isopropyl ester prodrug of the ribonucleoside analog EIDD-1931 with oral bioavailability.

Molnupiravir (EIDD-2801) is an orally bioavailable proagent of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza.

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Animal Model:C57BL/6 mice (intranasal infection with SARS-CoV)Dosage:50, 150, 500 mg/kg Administration:Oral; every 12 hours for 3 days Result:Body weight loss is significantly diminished or prevented.Animal Model: Ca/09-infected female ferrets Dosage:7 mg/kg Administration:Oral; twice daily for 3.5 days Result:Shed virus load and duration of fever were significantly reduced.

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Microbiology/Virology

Influenza Virus

Influenza Virus | SARS-CoV

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2492423-29-5

329.31

C13H19N3O7

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (151.83 mM; Ultrasonic )H2O : 12.5 mg/mL (37.96 mM; Ultrasonic)

CC(C)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc\c(=N/O)[nH]c1=O

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(-20℃)

With Ice Pack

≥ 2 years