R 125489( R125489 | Laninamivir )

Catalog No. M13161 CAS No. 203120-17-6

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Datasheet

HNMR

HPLC

MSDS

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Product Name

R 125489
Note

Research use only, not for human use.
Brief Description

R 125489 (Laninamivir) is a potent influenza neuraminidase (NA) inhibitor, inhibits the NA activities of various type A and B influenza viruses.
Description

R 125489 (Laninamivir) is a potent influenza neuraminidase (NA) inhibitor, inhibits the NA activities of various type A and B influenza viruses, including subtypes N1 to N9 and oseltamivir-resistant viruses.(In Vitro):Laninamivir (R 125489) inhibits efficiently common oseltamivir-resistant viruses, including those with the ubiquitous His274Tyr substitution.Laninamivir (R 125489) is potent against p57N2, p09N1 and N5 with a similar binding mode to Zanamivir.
In Vitro

Laninamivir (R 125489) inhibits efficiently common oseltamivir-resistant viruses, including those with the ubiquitous His274Tyr substitution.Laninamivir (R 125489) is potent against p57N2, p09N1 and N5 with a similar binding mode to Zanamivir.
In Vivo

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Synonyms

R125489 | Laninamivir
Pathway

Microbiology/Virology
Target

Influenza Virus
Recptor

Influenza Virus
Research Area

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Indication

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CAS Number

203120-17-6
Formula Weight

346.34
Molecular Formula

C13H22N4O7
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : 5 mg/mL (14.44 mM)
SMILES

O=C(C1=C[C@H](NC(N)=N)[C@@H](NC(C)=O)[C@@H](C[C@@H](OC)CO)O1)O
Chemical Name

(4S,5R,6R)-5-Acetamido-4-guanidino-6-((1R,2R)-2,3-dihydroxy-1-methoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylic acid

1. Yamashita M, et al. Antimicrob Agents Chemother. 2009 Jan;53(1):186-92. 2. Koyama K, et al. Antimicrob Agents Chemother. 2009 Nov;53(11):4845-51.

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