Cart
sales@molnova.com
Laninamivir
CAS No. 203120-46-1
Laninamivir( CS-8958 )
Catalog No. M13162 CAS No. 203120-46-1
Laninamivir (CS-8958) is a prodrug of the influenza neuraminidase (NA) inhibitor R-125489.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 53 | In Stock |
|
| 2MG | 31 | In Stock |
|
| 5MG | 51 | In Stock |
|
| 10MG | 86 | In Stock |
|
| 25MG | 181 | In Stock |
|
| 50MG | 268 | In Stock |
|
| 100MG | 349 | In Stock |
|
| 200MG | 479 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameLaninamivir
-
NoteResearch use only, not for human use.
-
Brief DescriptionLaninamivir (CS-8958) is a prodrug of the influenza neuraminidase (NA) inhibitor R-125489.
-
DescriptionLaninamivir (CS-8958) is a prodrug of the influenza neuraminidase (NA) inhibitor R-125489, shows long-acting anti-influenza virus activity.Influenza Approved(In Vitro):Laninamivir octanoate (CS-8958) shows inhibitory activity with an IC50 of 631-1170 nM, 39.2-221 nM and 128 nM to the H1N1 viruses strains, H3N2 viruses strains and H2N2 (A/Singapore/1/57) virus, respectively.(In Vivo):Laninamivir octanoate (CS-8958; 95 μg/kg; intranasal administration; three dose; at 4 h before and 4 h and 17 h postinfection) treatment shows significantly life-prolonging effect in infected model.
-
In VitroLaninamivir octanoate (CS-8958) shows inhibitory activity with an IC50 of 631-1170 nM, 39.2-221 nM and 128 nM to the H1N1 viruses strains, H3N2 viruses strains and H2N2 (A/Singapore/1/57) virus, respectively.
-
In VivoLaninamivir octanoate (CS-8958; 95 μg/kg; intranasal administration; three dose; at 4 h before and 4 h and 17 h postinfection) treatment shows significantly life-prolonging effect in infected model. Animal Model:Female BALB/c mice (5-6 weeks old) infected with influenza A virus A/PR/8/34 Dosage:0.2 μmol/kg (95 μg/kg) Administration:Intranasal administration; three dose; at 4 h before and 4 h and 17 h postinfection Result:Showed life-prolonging effect in infected model.
-
SynonymsCS-8958
-
PathwayMicrobiology/Virology
-
TargetInfluenza Virus
-
RecptorInfluenza Virus
-
Research AreaInfection
-
IndicationInfluenza
Chemical Information
-
CAS Number203120-46-1
-
Formula Weight472.539
-
Molecular FormulaC21H36N4O8
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (211.63 mM)
-
SMILESO=C(C1=C[C@H](NC(N)=N)[C@@H](NC(C)=O)[C@H]([C@H](OC)[C@H](O)COC(CCCCCCC)=O)O1)O
-
Chemical Name(4S,5R,6R)-5-acetamido-4-guanidino-6-[(1R,2R)-2-hydroxy-1-methoxy-3-(octanoyloxy)propyl]-5,6-dihydro-4H-pyran-2-carboxylic acid
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Yamashita M, et al. Antimicrob Agents Chemother. 2009 Jan;53(1):186-92.
2. Koyama K, et al. Antimicrob Agents Chemother. 2009 Nov;53(11):4845-51.
3. Kubo S, et al. Antimicrob Agents Chemother. 2010 Mar;54(3):1256-64.
4. Sugaya N, et al. Antimicrob Agents Chemother. 2010 Jun;54(6):2575-82.
molnova catalog
related products
-
3-?Phenyl-?N-?[1-?(p...
3-?Phenyl-?N-?[1-?(phenylmethyl)?-?4-?piperidinyl]?-tricyclo[3.3.1.13?7]?decane-?1-?carboxamide with antiviral activity against Ebola virus that targets the surface-exposed glycoprotein and inhibits viral entry into host cells.?In vitro studies in Vero cells revealed the compound inhibits the viral replication with EC50 of 0.38 μM.
-
Oplodiol
Oplodiol (Eudesm-7-ene-1β,4-diol), a sesquiterpene compoud, can be isolated from the flower buds of Magnolia fargesii.
-
EHNA hydrochloride
EHNA hydrochloride is a selective inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2) and adenosine deaminase (ADA) with anticancer activity, increasing intracellular adenosine concentration in a treatment time-dependent manner.
