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DIF-3
CAS No. 113411-17-9
DIF-3( —— )
Catalog No. M35425 CAS No. 113411-17-9
DIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 216 | In Stock |
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| 5MG | 235 | In Stock |
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| 10MG | 351 | In Stock |
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| 25MG | 588 | In Stock |
|
| 50MG | 821 | In Stock |
|
| 100MG | 1107 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2260 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDIF-3
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NoteResearch use only, not for human use.
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Brief DescriptionDIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins.
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DescriptionDIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. DIF-3 exerts a strong antiproliferative effect on the human cervical cancer cell line HeLa by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayWnt/Notch/Hedgehog
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TargetWnt/beta/catenin
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RecptorWnt/beta-catenin | GSK-3 | CDK
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Research Area——
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Indication——
Chemical Information
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CAS Number113411-17-9
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Formula Weight272.72
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Molecular FormulaC13H17ClO4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (366.68 mM; Ultrasonic )
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SMILESCCCCCC(=O)c1c(O)cc(OC)c(Cl)c1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Naoya Kubokura , et al. Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo. J Pharmacol Sci. 2015 Apr;127(4):446-55.?
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