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HDAC-IN-40
CAS No. 2463198-51-6
HDAC-IN-40( —— )
Catalog No. M35321 CAS No. 2463198-51-6
HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with a Ki of 60 nM for HDAC2 and 30 nM for HDAC6, exhibiting antitumor effects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 69 | In Stock |
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| 10MG | 112 | In Stock |
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| 25MG | 259 | In Stock |
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| 50MG | 375 | In Stock |
|
| 100MG | 533 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameHDAC-IN-40
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NoteResearch use only, not for human use.
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Brief DescriptionHDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with a Ki of 60 nM for HDAC2 and 30 nM for HDAC6, exhibiting antitumor effects.
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DescriptionHDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with Ki values of 60 nM and 30 nM for HDAC2 and HDAC6, respectively. HDAC-IN-40 had antitumor effects.
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In VitroHDAC-IN-40 (Compound 13d) shows antiproliferative activity against the cell line A2780 and Cal27 with IC50 values of 0.89 μM and 0.72 μM, respectively. HDAC-IN-40 induces accumulation of acetyl α-tubulin in Cal27 and Cal27CisR. HDAC-IN-40 enhances the Cisplatin-induced cytotoxicity via caspase-3/7 activation.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC
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Research Area——
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Indication——
Chemical Information
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CAS Number2463198-51-6
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Formula Weight326.35
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Molecular FormulaC15H22N2O6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (766.07 mM; Ultrasonic )
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SMILESCOc1cc(OC)cc(c1)C(=O)NOCCCCCC(=O)NO
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yodita Asfaha, et al. Novel alkoxyamide-based histone deacetylase inhibitors reverse cisplatin resistance in chemoresistant cancer cells. Bioorg Med Chem. 2020 Jan 1;28(1):115108. ?
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