HDAC-IN-40

Research use only, not for human use.

HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with a Ki of 60 nM for HDAC2 and 30 nM for HDAC6, exhibiting antitumor effects.

HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with Ki values of 60 nM and 30 nM for HDAC2 and HDAC6, respectively. HDAC-IN-40 had antitumor effects.

HDAC-IN-40 (Compound 13d) shows antiproliferative activity against the cell line A2780 and Cal27 with IC50 values of 0.89 μM and 0.72 μM, respectively. HDAC-IN-40 induces accumulation of acetyl α-tubulin in Cal27 and Cal27CisR. HDAC-IN-40 enhances the Cisplatin-induced cytotoxicity via caspase-3/7 activation.

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Cell Cycle/DNA Damage

HDAC

HDAC

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2463198-51-6

326.35

C15H22N2O6

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (766.07 mM; Ultrasonic )

COc1cc(OC)cc(c1)C(=O)NOCCCCCC(=O)NO

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(-20℃)

With Ice Pack

≥ 2 years