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Corin
CAS No. 1808113-09-8
Corin( —— )
Catalog No. M12765 CAS No. 1808113-09-8
Corin is a dual action LSD1/HDAC inhibitor (IC50=0.33/0.20 uM) that potently targets the CoREST complex.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 466 | In Stock |
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| 5MG | 432 | In Stock |
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| 10MG | 638 | In Stock |
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| 25MG | 1007 | In Stock |
|
| 50MG | 1330 | In Stock |
|
| 100MG | 1786 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCorin
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NoteResearch use only, not for human use.
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Brief DescriptionCorin is a dual action LSD1/HDAC inhibitor (IC50=0.33/0.20 uM) that potently targets the CoREST complex.
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DescriptionCorin is a dual action LSD1/HDAC inhibitor (IC50=0.33/0.20 uM) that potently targets the CoREST complex and shows more sustained inhibition of CoREST complex HDAC activity compared with entinostat; exhibits a superior anti-proliferative profile against several melanoma lines and cutaneous squamous cell carcinoma lines compared to its parent monofunctional inhibitors but is less toxic to melanocytes and keratinocytes; demonstrates effectivity in slowing tumor growth in a melanoma mouse xenograft model.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC
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Research Area——
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Indication——
Chemical Information
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CAS Number1808113-09-8
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Formula Weight428.536
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Molecular FormulaC26H28N4O2
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Purity>98% (HPLC)
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SolubilityDMSO : 100 mg/mL 233.36 mM; H2O : < 0.1 mg/mL
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SMILESC1C(C1N)C2=CC=C(C=C2)NC(=O)CCCC3=CC=C(C=C3)C(=O)NC4=CC=CC=C4N
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Chemical Name4-(4-((4-(2-aminocyclopropyl)phenyl)amino)-4-oxobutyl)-N-(2-aminophenyl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kalin JH, et al. Nat Commun. 2018 Jan 4;9(1):53.
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