TAK-418( —— )

Catalog No. M35103 CAS No. 1818252-53-7

TAK-418 is a selective and orally active inhibitor of LSD1/KDM1A enzyme with an IC50 of 2.9 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	387	In Stock
5MG	330	In Stock
10MG	521	In Stock
25MG	1064	In Stock
50MG	1404	In Stock
100MG	1879	In Stock
200MG	2539	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

TAK-418
Note

Research use only, not for human use.
Brief Description

TAK-418 is a selective and orally active inhibitor of LSD1/KDM1A enzyme with an IC50 of 2.9 nM.
Description

TAK-418 is a selective, orally active LSD1 (KDM1A) enzyme inhibitor with an IC50 of 2.9 nM. TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Chromatin/Epigenetic
Target

Histone Demethylase
Recptor

Histone Demethylase
Research Area

——
Indication

——

Chemical Information

CAS Number

1818252-53-7
Formula Weight

356.91
Molecular Formula

C17H25ClN2O2S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 55 mg/mL (154.10 mM; Ultrasonic (<60°C); )H2O : ≥ 16.67 mg/mL (46.71 mM)
SMILES

Cl.O=C(NC1CCOCC1)c1csc(c1)[C@@H]1C[C@H]1NCC1CC1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Baba R, et al. LSD1 enzyme inhibitor TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models. Sci Adv. 2021;7(11):eaba1187. Published 2021 Mar 12.?

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