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TAK-418
CAS No. 1818252-53-7
TAK-418( —— )
Catalog No. M35103 CAS No. 1818252-53-7
TAK-418 is a selective and orally active inhibitor of LSD1/KDM1A enzyme with an IC50 of 2.9 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 387 | In Stock |
|
| 5MG | 330 | In Stock |
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| 10MG | 521 | In Stock |
|
| 25MG | 1064 | In Stock |
|
| 50MG | 1404 | In Stock |
|
| 100MG | 1879 | In Stock |
|
| 200MG | 2539 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTAK-418
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NoteResearch use only, not for human use.
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Brief DescriptionTAK-418 is a selective and orally active inhibitor of LSD1/KDM1A enzyme with an IC50 of 2.9 nM.
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DescriptionTAK-418 is a selective, orally active LSD1 (KDM1A) enzyme inhibitor with an IC50 of 2.9 nM. TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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RecptorHistone Demethylase
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Research Area——
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Indication——
Chemical Information
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CAS Number1818252-53-7
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Formula Weight356.91
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Molecular FormulaC17H25ClN2O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 55 mg/mL (154.10 mM; Ultrasonic (<60°C); )H2O : ≥ 16.67 mg/mL (46.71 mM)
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SMILESCl.O=C(NC1CCOCC1)c1csc(c1)[C@@H]1C[C@H]1NCC1CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Baba R, et al. LSD1 enzyme inhibitor TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models. Sci Adv. 2021;7(11):eaba1187. Published 2021 Mar 12.?
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