Mc-VC-PAB-SN38( —— )

Catalog No. M35101 CAS No. 1801838-28-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Mc-VC-PAB-SN38
Note

Research use only, not for human use.
Brief Description

Mc-VC-PAB-SN38 consists of a cleavable ADC linker (Mc-VC-PAB) and SN38, which is part of an antibody-coupled reactive molecule commonly used to synthesize antibody-coupled reactive molecules (ADCs) that target sites of action.
Description

Mc-VC-PAB-SN38 consists a cleavable ADC linker (Mc-VC-PAB) and a DNA topoisomerase I inhibitor (SN38). Mc-VC-PAB-SN38 can be used in the synthesis of antibody-drug conjugates (ADCs).
In Vitro

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In Vivo

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Synonyms

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Pathway

Antibody Drug Conjugates (ADC)
Target

Drug-Linker Conjugates
Recptor

Drug-Linker Conjugates for ADC
Research Area

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Indication

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CAS Number

1801838-28-7
Formula Weight

991.05
Molecular Formula

C51H58N8O13
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 28.57 mg/mL (28.83 mM; Ultrasonic )
SMILES

CCc1c2Cn3c(cc4c(COC(=O)[C@@]4(CC)OC(=O)OCc4ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN5C(=O)C=CC5=O)C(C)C)cc4)c3=O)-c2nc2ccc(O)cc12
Chemical Name

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1. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.?

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