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SMCC-DM1

CAS No. 1228105-51-8

SMCC-DM1( DM1-SMCC )

Catalog No. M10886 CAS No. 1228105-51-8

A thioether linker conjugated with potent microtubule-disrupting agent DM1 (mertansine).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SMCC-DM1
  • Note
    Research use only, not for human use.
  • Brief Description
    A thioether linker conjugated with potent microtubule-disrupting agent DM1 (mertansine).
  • Description
    A thioether linker conjugated with potent microtubule-disrupting agent DM1 (mertansine).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    DM1-SMCC
  • Pathway
    Antibody Drug Conjugates (ADC)
  • Target
    Drug-Linker Conjugates
  • Recptor
    Drug-Linker Conjugates
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    1228105-51-8
  • Formula Weight
    1072.61164
  • Molecular Formula
    C51H66ClN5O16S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C[C@@H]1[C@@H]2C[C@](NC(O2)=O)(O)[C@H](OC)/C=C\C=C(C)\CC3=CC(N(C)C(C[C@@H](OC([C@@H](N(C(CCSC(C(N4CC5CCC(C(ON6C(CCC6=O)=O)=O)CC5)=O)CC4=O)=O)C)C)=O)[C@@]7(C)C1O7)=O)=C(Cl)C(OC)=C3
  • Chemical Name
    Maytansine, N2'-deacetyl-N2'-[3-[[1-[[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]thio]-1-oxopropyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Erickson HK, et al. Cancer Res. 2006 Apr 15;66(8):4426-33. 2. Ikeda H, et al. Clin Cancer Res. 2009 Jun 15;15(12):4028-37. 3. Erickson HK, et al. Bioconjug Chem. 2010 Jan;21(1):84-92. 4. Kellogg BA, et al. Bioconjug Chem. 2011 Apr 20;22(4):717-27.
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