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IHVR-17028
CAS No. 1428247-78-2
IHVR-17028( —— )
Catalog No. M35076 CAS No. 1428247-78-2
IHVR-17028 is a potent broad-spectrum ERα-glucosidase I (α-glucosidase I) inhibitor with IC50 of 0.24 μM and antiviral activity. IHVR-17028 inhibited BVDV, TCRV and DENV, and EC50 values were 0.4 μM, 0.26 μM and 0.3 μM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 434 | In Stock |
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| 5MG | 391 | In Stock |
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| 10MG | 543 | In Stock |
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| 25MG | 827 | In Stock |
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| 50MG | 1014 | In Stock |
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| 100MG | 1265 | In Stock |
|
| 200MG | 1702 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameIHVR-17028
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NoteResearch use only, not for human use.
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Brief DescriptionIHVR-17028 is a potent broad-spectrum ERα-glucosidase I (α-glucosidase I) inhibitor with IC50 of 0.24 μM and antiviral activity. IHVR-17028 inhibited BVDV, TCRV and DENV, and EC50 values were 0.4 μM, 0.26 μM and 0.3 μM, respectively.
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DescriptionIHVR-17028 is a potent and broad-spectrum antiviral agent. IHVR-17028 exhibits antiviral activity against BVDV, TCRV and DENV with EC50 values of 0.4 μM, 0.26 μM, 0.3 μM, respectively. IHVR-17028 is a potent ER α-glucosidase I inhibitor with an IC50 of 0.24 μM. IHVR-17028 can be used for infectious diseases research.
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In VitroIn virus yield reduction assays, IHVR-17028 inhibits viral activities with EC50 values of 0.4 μM, 0.26 μM, 0.3 μM for bovine viral diarrhea virus (BVDV) (NADL strain), tacaribe virus (TCRV) (11573 strain), DENV (serotype 2, New Guinea C), respectively. And in MTT assays, IHVR-17028 exhibits IC50 values of all >500 μM inMDBK, Huh7.5 or BHK cells.
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In VivoIn Pharmacokinetic analysis in rats, IHVR17028 (oral gavage; 75 mg/kg) shows a Cmax?value of 0.18 μg/ml; the Tmax value is 1.56 hours; and the F% value is 12% after PO administration, the T1/2 value is 0.88 hour after iv. adminstration.IHVR-17028 (oral gavage; 25-50 mg/kg; treatment 1 day prior to virus challenging) exhibits significant protection in mouse model of lethal MARV infection.Animal Model:BALB/c mice are challenged with 1,000 PFU mouse adapted MARV via IP injection Dosage:50 mg/kg Administration:Treatment 1 day prior to virus challenging Result:Exhibited protection in mouse when the treatment is initiated 1 day prior to virus challenging.Animal Model:C57B1/6 mice challenged with 1,000 PFU mouse adapted EBOV Dosage:25 mg/kg Administration:Twice daily at 12 h interval; starting 4 h post infection for 10 days Result:Inhibited EBOV infection in mice.
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Synonyms——
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PathwayMicrobiology/Virology
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TargetInfluenza Virus
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RecptorInfluenza Virus | Glucosidase
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Research Area——
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Indication——
Chemical Information
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CAS Number1428247-78-2
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Formula Weight428.61
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Molecular FormulaC23H44N2O5
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Purity>98% (HPLC)
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Solubility——
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SMILESC(CCCCCN(C(C(C)(C)C)=O)C1CCCCC1)N2[C@H](CO)[C@@H](O)[C@H](O)[C@@H](O)C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jinhong Chang, et al. Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses.Antiviral Res. 2013 Jun;98(3):432-40.?
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