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CBS1117

CAS No. 959245-08-0

CBS1117( —— )

Catalog No. M22993 CAS No. 959245-08-0

CBS1117 is an inhibitor virus entry inhibitor(IC50 of 70 nM for influenza A virus), A/Puerto Rico/8/34 (H1N1). It interferes with the hemagglutinin (HA)-mediated fusion process.CBS1117 which has a 50% inhibitory concentration of 70 nM and a selectivity index of ~4000 against A/Puerto Rico/8/34 (H1N1) infection in human lung epithelial cell line (A549).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CBS1117
  • Note
    Research use only, not for human use.
  • Brief Description
    CBS1117 is an inhibitor virus entry inhibitor(IC50 of 70 nM for influenza A virus), A/Puerto Rico/8/34 (H1N1). It interferes with the hemagglutinin (HA)-mediated fusion process.CBS1117 which has a 50% inhibitory concentration of 70 nM and a selectivity index of ~4000 against A/Puerto Rico/8/34 (H1N1) infection in human lung epithelial cell line (A549).
  • Description
    CBS1117 is an inhibitor virus entry inhibitor(IC50 of 70 nM for influenza A virus), A/Puerto Rico/8/34 (H1N1). It interferes with the hemagglutinin (HA)-mediated fusion process.CBS1117 which has a 50% inhibitory concentration of 70 nM and a selectivity index of ~4000 against A/Puerto Rico/8/34 (H1N1) infection in human lung epithelial cell line (A549).
  • In Vitro
    CBS1117 has a lower IC50 value of 70 nM and higher CC50 value of 274 μM, leading to an excellent antiviral selectivity index value (SI value of 3914) in human lung epithelial cell line (A549).
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Microbiology/Virology
  • Target
    Influenza Virus
  • Recptor
    influenza A virus
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    959245-08-0
  • Formula Weight
    315.24
  • Molecular Formula
    C15H20Cl2N2O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (793.05 mM)
  • SMILES
    O=C(NC1CCN(C(C)C)CC1)C2=C(Cl)C=CC=C2Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hussein AFA, et al. Identification of entry inhibitors with 4-aminopiperidine scaffold targeting group 1 influenza A virus. Antiviral Res. 2020 May;177:104782.
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