ML 209( —— )

Catalog No. M34963 CAS No. 1334526-14-5

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Datasheet

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Product Name

ML 209
Note

Research use only, not for human use.
Brief Description

ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription in HEK293T cells expressing the human receptor (IC50= 300 nM).
Description

(±)-ML 209 (compound 4n), a diphenylpropanamide, is a retinoic acid-related orphan receptor RORγ antagonist with an IC50 of 1.1 μM. (±)-ML 209 inhibits RORγt transcriptional activity with an IC50 of 300 nM in HEK293t cells. (±)-ML 209 inhibits the transcriptional activity of RORγt, but not RORα in cells. (±)-ML 209 selectively inhibits murine Th17 cell differentiation without affecting the differentiation of na ve CD4+ T cells into other lineages, including Th1 and regulatory T cells.
In Vitro

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In Vivo

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Synonyms

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Pathway

Nuclear Receptor/Transcription Factor
Target

ROR
Recptor

ROR
Research Area

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Indication

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CAS Number

1334526-14-5
Formula Weight

441.52
Molecular Formula

C25H31NO6
Purity

>98% (HPLC)
Solubility

——
SMILES

C(CC(=O)N1C[C@@H](C)C[C@@H](C)C1)(C2=C(OC)C=C(OC)C=C2O)C=3C=C4C(=CC3)OCO4
Chemical Name

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1. Jun R Huh, et al. Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors. ACS Med Chem Lett. 2013 Jan 10;4(1):79-84. ?

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