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SR2211
CAS No. 1359164-11-6
SR2211( —— )
Catalog No. M33503 CAS No. 1359164-11-6
SR2211 is a specific modulator and an inverse agonist of RORγ(IC50 = 320 nM, Ki = 105 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 117 | In Stock |
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| 5MG | 92 | In Stock |
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| 10MG | 180 | In Stock |
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| 25MG | 275 | In Stock |
|
| 50MG | 368 | In Stock |
|
| 100MG | 523 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1107 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSR2211
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NoteResearch use only, not for human use.
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Brief DescriptionSR2211 is a specific modulator and an inverse agonist of RORγ(IC50 = 320 nM, Ki = 105 nM).
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DescriptionSR2211 is a potent, selective synthetic RORγ modulator and functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM.
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In VitroThe treatment of EL4 with SR2211 represses the IL-17 gene expression. Similarly, the expression of IL-23 receptor (Il23r) is significantly inhibited by SR2211. Treatment of EL-4 cells with SR2211 results in significant inhibition of IL-17 intracellular staining as compared to vehicle treated cells.
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In Vivo——
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Synonyms——
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PathwayNuclear Receptor/Transcription Factor
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TargetROR
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RecptorROR
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Research Area——
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Indication——
Chemical Information
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CAS Number1359164-11-6
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Formula Weight527.48
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Molecular FormulaC26H24F7N3O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (189.58 mM; Ultrasonic )
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SMILESOC(c1ccc(c(F)c1)-c1ccc(CN2CCN(Cc3ccncc3)CC2)cc1)(C(F)(F)F)C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kumar N, et al. Identification of SR2211: a potent synthetic RORγ-selective modulator. ACS Chem Biol. 2012 Apr 20;7(4):672-7.?
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