3-Oxo-5β-cholanoic acid

Research use only, not for human use.

3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd: 1.13 μM).

3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd: 1.13 μM).(In Vitro):Treatment with 3-Oxo-5β-cholanoic acid significantly reduced the activity of the RORγt reporter. 3-Oxo-5β-cholanoic acid probably inhibits TH17 cell differentiation by physically interacting with RORγt, and inhibiting its transcriptional activity.(In Vivo):3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (0.3% (w/w); p.o.; for 1 week) significantly reduces the percentage of ileal TH17 cells.

Treatment with 3-Oxo-5β-cholanoic acid significantly reduced the activity of the RORγt reporter. These data suggest that 3-Oxo-5β-cholanoic acid probably inhibits TH17 cell differentiation by physically interacting with RORγt, and inhibiting its transcriptional activity.

3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (0.3% (w/w); p.o.; for 1 week) significantly reduces the percentage of ileal TH17 cells. Animal Model:B6 Jax mice (with a faecal slurry containing SFB)Dosage:0.3% (w/w)Administration:Gavaged; for 1 week Result:Significantly reduced the percentage of ileal TH17 cells.

Dehydrolithocholic acid | 3-oxoLCA

Nuclear Receptor/Transcription Factor

ROR

KSP

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1553-56-6

374.565

C24H38O3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (266.98 mM)

C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C

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(-20℃)

With Ice Pack

≥ 2 years