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CU-CPD107
CAS No. 2573912-32-8
CU-CPD107( —— )
Catalog No. M34755 CAS No. 2573912-32-8
CU-CPD107 is a selective agonist of toll-like receptor 8 (TLR8) and also shows activation activity against ssRNA ligands. CU-CPD107 acts as an inhibitor of TLR8 signaling in the presence of R848 (IC50=13.7 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 130 | In Stock |
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| 10MG | 206 | In Stock |
|
| 25MG | 377 | In Stock |
|
| 50MG | 525 | In Stock |
|
| 100MG | 737 | In Stock |
|
| 200MG | 1004 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCU-CPD107
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NoteResearch use only, not for human use.
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Brief DescriptionCU-CPD107 is a selective agonist of toll-like receptor 8 (TLR8) and also shows activation activity against ssRNA ligands. CU-CPD107 acts as an inhibitor of TLR8 signaling in the presence of R848 (IC50=13.7 μM).
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DescriptionCU-CPD107 is a potent, selective toll-like receptor 8 (TLR 8) agonist. CU-CPD107 inhibits TLR8 signaling. CU-CPD107 converts to synergistic agonist activities in the presence of ssRNA and induces TLR8 signaling. CU-CPD107 inhibits proinflammatory factor expression and avoids immune responses in the presence of ssRNA.
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In VitroCU-CPD107 (HEK-Blue hTLR8 cells) inhibits R848-induced signaling with an IC50 value of 13.7?μM.CU-CPD107 (0-100 μM; HEK-Blue hTLR8 cells) converts to an agonist in the presence of ssRNA.CU-CPD107 (100 μM; HEK-Blue hTLR8 cells) decreases IFN-β, TNF-α, IL-1β, IL-6 and IL-8 mRNA expression levels.
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In Vivo——
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Synonyms——
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PathwayImmunology/Inflammation
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TargetTLR
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RecptorTLR
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Research Area——
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Indication——
Chemical Information
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CAS Number2573912-32-8
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Formula Weight400.25
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Molecular FormulaC16H21IN2O2
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Purity>98% (HPLC)
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Solubility——
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SMILESC(C(C)(C)O)N1C(=C(I)N=C1COCC)C2=CC=CC=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yang Y, et, al. Tetrasubstituted imidazoles as incognito Toll-like receptor 8?a(nta)gonists. Nat Commun. 2021 Jul 16;12(1):4351.?
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