Loxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities.

GSK2245035 is a highly potent, selective TLR7 agonist that selectively induces TFN-α in PBMC assays with pEC50 of 9.3, >2 logs selectivity over TNFα pEC50.

CU-115 is a selective antagonist of TLR8 with IC50s of 1.04 μM and >50 μM for TLR8 and TLR7, respectively.