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Isatoribine

CAS No. 122970-40-5

Isatoribine( ANA245 | 7-Thia-8-oxoguanosine | Immunosine )

Catalog No. M10905 CAS No. 122970-40-5

Isatoribine (ANA245;7-Thia-8-oxoguanosine;Immunosine) is a nucleoside analogue, selective agonist of TLR7 with significant antiviral effect and mmunoenhancing activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Isatoribine
  • Note
    Research use only, not for human use.
  • Brief Description
    Isatoribine (ANA245;7-Thia-8-oxoguanosine;Immunosine) is a nucleoside analogue, selective agonist of TLR7 with significant antiviral effect and mmunoenhancing activity.
  • Description
    Isatoribine (ANA245;7-Thia-8-oxoguanosine;Immunosine) is a nucleoside analogue, selective agonist of TLR7 with significant antiviral effect and mmunoenhancing activity; stimulates proliferation of thymocytes in vitro, stimulates IL-2 production and the expression of activation markers (CD25 and CD71); reduces plasma virus concentration in chronic HCV infection; also increase the efficacy of a weakly immunogenic murine L1210 leukemia vaccine in vivo.HCV Infection Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ANA245 | 7-Thia-8-oxoguanosine | Immunosine
  • Pathway
    Immunology/Inflammation
  • Target
    TLR
  • Recptor
    TLR
  • Research Area
    Infection
  • Indication
    HCV Infection

Chemical Information

  • CAS Number
    122970-40-5
  • Formula Weight
    316.288
  • Molecular Formula
    C10H12N4O6S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(C1C(C(C(O1)N2C3=C(C(=O)NC(=N3)N)SC2=O)O)O)O
  • Chemical Name
    5-amino-3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4H-[1,3]thiazolo[4,5-d]pyrimidine-2,7-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Horsmans Y, et al. Hepatology. 2005 Sep;42(3):724-31. 2. Smee DF, et al. Antiviral Res. 1991 Mar-Apr;15(3):229-39. 3. Jin A, et al. Cell Immunol. 1990 Apr 1;126(2):414-9. 4. Sharma BS, et al. Cancer Immunol Immunother. 1991;33(2):109-14.
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