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Giripladib

CAS No. 865200-20-0

Giripladib( —— )

Catalog No. M34608 CAS No. 865200-20-0

Giripladib (PLA695)(PLX-695) is a cPLA2-specific inhibitor that inhibits the radiation-induced increase of phosphorylated ERK and phosphorylated Akt in endothelial cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 623 In Stock
5MG 426 In Stock
10MG 625 In Stock
25MG 938 In Stock
50MG 1283 In Stock
100MG 1758 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Giripladib
  • Note
    Research use only, not for human use.
  • Brief Description
    Giripladib (PLA695)(PLX-695) is a cPLA2-specific inhibitor that inhibits the radiation-induced increase of phosphorylated ERK and phosphorylated Akt in endothelial cells.
  • Description
    Giripladib (PLA-695) is a indole-based inhibitor of cytosolic phospholipase A2 (cPLA2). Giripladib can be used for osteoarthritis and breast cancer research.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phospholipase
  • Recptor
    Phospholipase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    865200-20-0
  • Formula Weight
    745.25
  • Molecular Formula
    C41H36ClF3N2O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(N1C(CCNS(CC2=C(C(F)(F)F)C=CC=C2)(=O)=O)=C(CCCC3=CC=C(C(O)=O)C=C3)C=4C1=CC=C(Cl)C4)(C5=CC=CC=C5)C6=CC=CC=C6
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kokotos G, et al. Inhibition of group IVA cytosolic phospholipase A2 by thiazolyl ketones in vitro, ex vivo, and in vivo. J Med Chem. 2014 Sep 25;57(18):7523-35.?
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