Cart
sales@molnova.com
VU 0469650
CAS No. 1443748-47-7
VU 0469650( —— )
Catalog No. M34469 CAS No. 1443748-47-7
VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 83 | In Stock |
|
| 5MG | 72 | In Stock |
|
| 10MG | 110 | In Stock |
|
| 25MG | 221 | In Stock |
|
| 50MG | 323 | In Stock |
|
| 100MG | 479 | In Stock |
|
| 200MG | 662 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameVU 0469650
-
NoteResearch use only, not for human use.
-
Brief DescriptionVU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).
-
DescriptionVU0469650 is a potent, selective and CNS-penetrated negative allosteric modulator of mGlu1 receptor, with an IC50 of 99 nM.
-
In Vitro——
-
In VivoVU0469650 (male Sprague-Dawley rats, 0.2 mg/kg, IV, once) exhibits moderate to high clearance, a moderate volume of distribution, and a half-life of approximately 1 hour.VU0469650 (male Sprague-Dawley rats, 10 mg/kg, IP, once) shows an excellent selectivity profile and good exposure in both plasma and brain samples.
-
Synonyms——
-
PathwayNeuroscience
-
TargetGluR
-
RecptorGluR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1443748-47-7
-
Formula Weight364.48
-
Molecular FormulaC22H28N4O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC(=O)(C12CC3CC(C1)CC(C2)C3)N4[C@H](C)CN(CC4)C5=C(C#N)N=CC=C5
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Lovell KM, Felts AS, Rodriguez AL, et al. N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats. Bioorg Med Chem Lett. 2013;23(13):3713-3718.?
molnova catalog
related products
-
7-Chlorokynurenic ac...
7-Chlorokynurenic acid is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site.
-
YM90K hydrochloride
YM90K hydrochloride is an antagonist of AMPA receptor.
-
NS-102
NS-102 is a glutamate receptor and NMDA receptor antagonist that inhibits erythrocyanine (GluK2), which reduces glur6 receptor-mediated currents, and inhibits specific binding to the glur6 receptor.
