TDRL-551( —— )

Catalog No. M34443 CAS No. 1644626-43-6

TDRL-551 is a novel and potent replication protein A (RPA) inhibitor (IC50=18 μM) with potential anticancer activity.

Purity : >98% (HPLC)

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Biological Information

Product Name

TDRL-551
Note

Research use only, not for human use.
Brief Description

TDRL-551 is a novel and potent replication protein A (RPA) inhibitor (IC50=18 μM) with potential anticancer activity.
Description

TDRL-551 is a potent replication protein A (RPA) inhibitor (IC50=18 μM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation.
In Vitro

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In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

1644626-43-6
Formula Weight

591.83
Molecular Formula

C25H23ClIN3O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 62.5 mg/mL (105.60 mM; Ultrasonic )
SMILES

CCOc1ccc2cc(C3CC(=NN3C(=O)CCCC(O)=O)c3ccc(I)cc3)c(Cl)nc2c1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Mishra AK, et al. Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer. Biochem Pharmacol. 2015;93(1):25-33. ?

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