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TDRL-551

CAS No. 1644626-43-6

TDRL-551( —— )

Catalog No. M34443 CAS No. 1644626-43-6

TDRL-551 is a novel and potent replication protein A (RPA) inhibitor (IC50=18 μM) with potential anticancer activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 223 In Stock
5MG 202 In Stock
10MG 297 In Stock
25MG 630 In Stock
50MG 986 In Stock
100MG 1609 In Stock
200MG 2167 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    TDRL-551
  • Note
    Research use only, not for human use.
  • Brief Description
    TDRL-551 is a novel and potent replication protein A (RPA) inhibitor (IC50=18 μM) with potential anticancer activity.
  • Description
    TDRL-551 is a potent replication protein A (RPA) inhibitor (IC50=18 μM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1644626-43-6
  • Formula Weight
    591.83
  • Molecular Formula
    C25H23ClIN3O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (105.60 mM; Ultrasonic )
  • SMILES
    CCOc1ccc2cc(C3CC(=NN3C(=O)CCCC(O)=O)c3ccc(I)cc3)c(Cl)nc2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mishra AK, et al. Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer. Biochem Pharmacol. 2015;93(1):25-33. ?
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