ER 50891( —— )

Catalog No. M33848 CAS No. 187400-85-7

ER-50891 is a potent retinoic acid receptor alpha (RARα) antagonist. er-50891 reduces the inhibitory effect of allosteric retinoic acid and restores osteoblast differentiation induced by bone morphogenetic protein 2.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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5MG	416	In Stock
10MG	549	In Stock
25MG	881	In Stock
50MG	1172	In Stock
100MG	1562	In Stock
200MG	2111	In Stock
500MG	Get Quote	In Stock
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Biological Information

Product Name

ER 50891
Note

Research use only, not for human use.
Brief Description

ER-50891 is a potent retinoic acid receptor alpha (RARα) antagonist. er-50891 reduces the inhibitory effect of allosteric retinoic acid and restores osteoblast differentiation induced by bone morphogenetic protein 2.
Description

ER-50891 is a potent antagonist of retinoic acid receptor α(RARα). ER-50891 significantly attenuates ATRA's inhibitive effects on BMP 2-induced osteoblastogenesis.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

Retinoid Receptor
Recptor

Retinoid Receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

187400-85-7
Formula Weight

432.51
Molecular Formula

C29H24N2O2
Purity

>98% (HPLC)
Solubility

——
SMILES

C(C)(C)C=1C2=C(C(=CC(=N2)C=3NC(=CC3)C4=CC=C(C(O)=O)C=C4)C5=CC=CC=C5)C=CC1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Batran RZ, et al. New quinolone derivatives as neuropeptide S receptor antagonists: Design, synthesis, homology modeling, dynamic simulations and modulation of Gq/Gs signaling pathways. Bioorg Chem. 2021;111:104817.?

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