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AMG-Tie2-1
CAS No. 870223-96-4
AMG-Tie2-1( —— )
Catalog No. M33796 CAS No. 870223-96-4
AMG-Tie2-1 is a potent inhibitor of endothelial endothelial cell kinase 2 (Tie2) and VEGFR2 with anticancer and antitumor activity that affects cardiovascular production, and may be used in the study of cardiovascular disease and cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 154 | In Stock |
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| 10MG | 226 | In Stock |
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| 25MG | 372 | In Stock |
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| 50MG | 621 | In Stock |
|
| 100MG | 1014 | In Stock |
|
| 200MG | 1516 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAMG-Tie2-1
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NoteResearch use only, not for human use.
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Brief DescriptionAMG-Tie2-1 is a potent inhibitor of endothelial endothelial cell kinase 2 (Tie2) and VEGFR2 with anticancer and antitumor activity that affects cardiovascular production, and may be used in the study of cardiovascular disease and cancer.
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DescriptionAMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) with an IC50 of 1 nM. AMG-Tie2-1 is a VEGFR2 inhibitor with an IC50 of 3 nM.
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In VitroAMG-Tie2-1 (compound 15) inhibits Tie-2 phosphorylation in EA.hy926 human endothelial cells (IC50=10 nM).
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetVEGFR
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RecptorVEGFR
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Research Area——
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Indication——
Chemical Information
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CAS Number870223-96-4
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Formula Weight479.45
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Molecular FormulaC25H20F3N5O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC1=CC=CC(=C1)C(F)(F)F)C2=CC=C(C(OC=3N=CC=CC3C4=NC(=NC=C4)NC)=C2)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Brian L Hodous, et al. Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor. J Med Chem. 2007 Feb 22;50(4):611-26.?
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