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VEGFR-2-IN-9
CAS No. 408502-06-7
VEGFR-2-IN-9( —— )
Catalog No. M32750 CAS No. 408502-06-7
VEGFR-2-IN-9 (KDR-in-4) is a potent KDR/VEGFR2 inhibitor with an IC50 of 7 nM, suitable for breast cancer research.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 1064 | Get Quote |
|
| 5MG | 1710 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameVEGFR-2-IN-9
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NoteResearch use only, not for human use.
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Brief DescriptionVEGFR-2-IN-9 (KDR-in-4) is a potent KDR/VEGFR2 inhibitor with an IC50 of 7 nM, suitable for breast cancer research.
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DescriptionVEGFR-2-IN-9 (KDR-in-4) is a potent kinase insert domain-containing receptor (KDR/VEGFR2) inhibitor with an IC50 of 7 nM.
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In VitroKDR (kinase insert domain-containing receptor) is one of the human tyrosine kinases that has a high affinity for vascular endothelial growth factor (VEGF) and is believed to be a primary mediator of tumor-induced angiogenesis.
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In VivoKDR-in-4 may prove to be useful for the treatment of a variety of ocular neovascular diseases using a convenient oral dosing regimen. At doses of 100 mg/kg, KDR-in-4 results in a 98% reduction in lesion size in the rat choroidal neovascularization (CNV) model. 30 mg/kg doses of KDR-in-4 shows a 70% and 80% reduction in lesion size in the laser CNV and rat oxygen induced retinopathy (OIR) models, respectively.
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Synonyms——
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PathwayAngiogenesis
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TargetVEGFR
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RecptorVEGFR
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Research Area——
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Indication——
Chemical Information
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CAS Number408502-06-7
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Formula Weight391.46
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Molecular FormulaC23H25N3O3
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1NC=2C=CC=CC2C=C1C3=CC4=CC(OCCN(C)CCOC)=CC=C4N3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fang YQ, et al. Efficient syntheses of KDR kinase inhibitors using a Pd-catalyzed tandem C-N/Suzuki coupling as the key step. J Org Chem. 2007 Feb 16;72(4):1341-6.?
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