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AG 045572
CAS No. 263847-55-8
AG 045572( —— )
Catalog No. M33779 CAS No. 263847-55-8
AG 045572 is a potent GnRH receptor antagonist that inhibits the GnRH receptor in humans and rats with Ki values of 6.0 nM and 3.8 nM, respectively.AG 045572 is metabolized by CYP3A and inhibits testosterone.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 93 | In Stock |
|
| 10MG | 150 | In Stock |
|
| 25MG | 302 | In Stock |
|
| 50MG | 462 | In Stock |
|
| 100MG | 672 | In Stock |
|
| 200MG | 928 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAG 045572
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NoteResearch use only, not for human use.
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Brief DescriptionAG 045572 is a potent GnRH receptor antagonist that inhibits the GnRH receptor in humans and rats with Ki values of 6.0 nM and 3.8 nM, respectively.AG 045572 is metabolized by CYP3A and inhibits testosterone.
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DescriptionAG-045572 is a GnRH receptor antagonist with Kis of 6.0 nM and 3.8 nM for human and rat GnRH receptor, respectively. AG-045572 is metabolized by CYP3A and ressuppresses testosterone.
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In VitroAG-045572 (10 μM, 40 min, for human liver microsomes; 10 μM, 10 min, for male rat liver microsomes; 1 μM, 10 min, for female rat liver microsomes) .
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In VivoAnimal Model:Male rats were surgically castrated via scrotal approach under halothane anesthesia and allowed 14 days post-operative recovery prior to studyDosage:10 mg/kg, 20 mg/kg; 40 mg/kg Administration: administered acutely at 10 mg/kg (i.v.) or 20 mg/kg (p.o.), one time; For multiple-dose pretreatment, male rats at 40 mg/kg, i.m. twice a day for 3 days.Result:Showed medium T1/2, CL and Vss but oral bioavailability was low, in female rats the bioavailability was much higher (24%)Became similar to those in female and castrated male rats.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetP450
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RecptorP450 | GNRH Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number263847-55-8
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Formula Weight491.62
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Molecular FormulaC30H37NO5
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1(C)C=2C(=CC(C)=C(CC=3OC(C(NC4=C(OC)C=C(OC)C=C4OC)=O)=CC3)C2)C(C)(C)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Iatsimirskaia EA, et al. Effect of testosterone suppression on the pharmacokinetics of a potent gnRH receptor antagonist. Pharm Res. 2002 Feb;19(2):202-8. ?
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