DADPS Biotin Azide

Research use only, not for human use.

Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a PEGylated PROTAC linker suitable for PROTAC synthesis .

Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

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PROTACs

PROTAC

PROTAC Linker

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1260247-50-4

886.18

C43H67N7O9SSi

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (112.84 mM; Ultrasonic )

[Si](OC(CNC(CCOCCOCCOCCOCCNC(CCCC[C@H]1[C@@]2([C@](CS1)(NC(=O)N2)[H])[H])=O)=O)(C)C)(OCCCCCCN=[N+]=[N-])(C3=CC=CC=C3)C4=CC=CC=C4

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(-20℃)

With Ice Pack

≥ 2 years