Cart
sales@molnova.com
CCT-367766
CAS No. 2229856-58-8
CCT-367766( CCT367766 | CCT 367766 )
Catalog No. M13570 CAS No. 2229856-58-8
CCT-367766 (CCT367766) is a novel heterobifunctional PROTAC that binds and degrades the putative transcription factor regulator Pirin in cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 686 | In Stock |
|
| 10MG | 938 | In Stock |
|
| 25MG | 1444 | In Stock |
|
| 50MG | 1841 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameCCT-367766
-
NoteResearch use only, not for human use.
-
Brief DescriptionCCT-367766 (CCT367766) is a novel heterobifunctional PROTAC that binds and degrades the putative transcription factor regulator Pirin in cells.
-
DescriptionCCT-367766 (CCT367766) is a novel heterobifunctional PROTAC that binds and degrades the putative transcription factor regulator Pirin in cells.
-
In VitroCCT367766 (50-1500 nM; 24 hours) demonstates the depletion of pirin protein as a?the time-dependent hook-effect in SK-OV-3 human ovarian cancer cells.CCT367766 (0.5-50 nM; 2 hours) demonstrates the concentration-dependent depletion of pirin protein after 2 h exposure in SK-OV-3 cells.CCT367766 (0.5-50 nM; 2 hours) dose-dependently rescuses pirin expression from pretreatment of chlorobisamide in SK-OV-3 cells.Western Blot AnalysisCell Line:SK-OV-3 human ovarian cancer cells Concentration:50, 150, 250, 500 and 1500 nMIncubation Time:2 hours, 4 hours, 24 hours Result:Decreased pirin protein expression.Western Blot Analysis Cell Line:SK-OV-3 human ovarian cancer cells Concentration:0.5, 1, 2.5, 5, 7.5, 10, 25, and 50 nM Incubation Time:2 hours Result:Completely degraded pirin just at50 nM treatment.
-
In Vivo——
-
SynonymsCCT367766 | CCT 367766
-
PathwayPROTACs
-
TargetPROTAC
-
RecptorPROTAC
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2229856-58-8
-
Formula Weight946.41
-
Molecular FormulaC49H48ClN7O11
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(C1=CC=C2N=C(CN3CCN(CCOCCOCCOC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)CC3)C=CC2=C1)NC7=CC(NC(C8=CC=C9OCCOC9=C8)=O)=CC=C7Cl
-
Chemical NameN-(2-Chloro-5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)phenyl)-2-((4-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)methyl)quinoline-6-carboxamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
-
Pentaethylene glycol
Pentaethylene glycol (3,6,9,12-Tetraoxatetradecane-1,14-diol) is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.
-
DBCO-S-S-PEG3-biotin
DBCO-S-S-PEG3-biotin is a cleavable reagent for introduction of a biotin moiety to azide-containing biomolecules using copper-free Click Chemistry.?The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP to remove the biotin label.?PEG Linkers can be used in the synthesis of PROTACs.
-
m-PEG24-NH2
m-PEG24-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
