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BRD4 degrader AT1
CAS No. 2098836-45-2
BRD4 degrader AT1( BRD4 PROTAC AT1 )
Catalog No. M13321 CAS No. 2098836-45-2
BRD4 degrader AT1 is a highly selective BED4 degrader (PROTAC), exhibits highly selective depletion of BRD4 in cells with negligible activity against BRD2 and BRD3.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 250 | In Stock |
|
| 10MG | 433 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBRD4 degrader AT1
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NoteResearch use only, not for human use.
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Brief DescriptionBRD4 degrader AT1 is a highly selective BED4 degrader (PROTAC), exhibits highly selective depletion of BRD4 in cells with negligible activity against BRD2 and BRD3.
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DescriptionBRD4 degrader AT1 is a highly selective BED4 degrader (PROTAC), exhibits highly selective depletion of BRD4 in cells with negligible activity against BRD2 and BRD3.
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In Vitro——
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In Vivo——
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SynonymsBRD4 PROTAC AT1
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PathwayPROTACs
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TargetPROTAC
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RecptorPROTAC
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number2098836-45-2
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Formula Weight972.68
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Molecular FormulaC48H58ClN9O5S3
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Purity>98% (HPLC)
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SolubilityDMSO : 100 mg/mL 102.81 mM
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SMILESCC1=C(C2=CC=C(CNC([C@H]3N(C([C@@H](NC(C)=O)C(C)(SCCCCCCNC(C[C@H]4C5=NN=C(C)N5C(SC(C)=C6C)=C6C(C7=CC=C(Cl)C=C7)=N4)=O)C)=O)C[C@H](O)C3)=O)C=C2)SC=N1
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Chemical Name(2S,4R)-1-((R)-2-acetamido-3-((6-(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamido)hexyl)thio)-3-methylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.
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