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dBET57
CAS No. 1883863-52-2
dBET57( dBET57 )
Catalog No. M12937 CAS No. 1883863-52-2
dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC), exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=500 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 169 | In Stock |
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| 5MG | 93 | In Stock |
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| 10MG | 150 | In Stock |
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| 25MG | 278 | In Stock |
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| 50MG | 423 | In Stock |
|
| 100MG | 612 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1265 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamedBET57
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NoteResearch use only, not for human use.
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Brief DescriptiondBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC), exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=500 nM).
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DescriptiondBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC), exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=500 nM), but is inactive on BRD4 BD2.
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In Vitro——
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In Vivo——
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SynonymsdBET57
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PathwayPROTACs
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TargetPROTAC
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RecptorPROTAC
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Research Area——
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Indication——
Chemical Information
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CAS Number1883863-52-2
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Formula Weight699.183
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Molecular FormulaC34H31ClN8O5S
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Purity>98% (HPLC)
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SolubilityDMSO : 250 mg/mL 357.56 mM
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SMILESO=C(NCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)C[C@H]4C5=NN=C(C)N5C6=C(C(C)=C(C)S6)C(C7=CC=C(Cl)C=C7)=N4
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Chemical Name2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nowak RP, et al. Nat Chem Biol. 2018 Jun 11. doi: 10.1038/s41589-018-0055-y.
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