dBET57( dBET57 )

Catalog No. M12937 CAS No. 1883863-52-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

dBET57
Note

Research use only, not for human use.
Brief Description

dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC), exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=500 nM).
Description

dBET57 is a novel BRD4 heterobifunctional small-molecule ligand (PROTAC), exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=500 nM), but is inactive on BRD4 BD2.
In Vitro

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In Vivo

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Synonyms

dBET57
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

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Indication

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CAS Number

1883863-52-2
Formula Weight

699.183
Molecular Formula

C34H31ClN8O5S
Purity

>98% (HPLC)
Solubility

DMSO : 250 mg/mL 357.56 mM
SMILES

O=C(NCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)C[C@H]4C5=NN=C(C)N5C6=C(C(C)=C(C)S6)C(C7=CC=C(Cl)C=C7)=N4
Chemical Name

2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide

1. Nowak RP, et al. Nat Chem Biol. 2018 Jun 11. doi: 10.1038/s41589-018-0055-y.

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