Cystamine

Research use only, not for human use.

Cystamine (2,2'-Disulfanediyldiethanamine) is an inhibitor of transglutaminase and inhibits caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used in studies about Huntington's diseases.

Cystamine is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) .

Cystamine has inhibition activity for caspase-3 with an IC50 value of 23.6 μM.Cystamine (0-500 μM; 0-16 h) inhibits recombinant active caspase-3 in a concentration-dependent manner. Cystamine (250 μM; 10 h) robustly increases the levels of glutathione.Western Blot Analysis Cell Line:uman neuroblastoma SH-SY5Y cells Concentration:250, 500 μM Incubation Time:0-16 h Result:Inhibited the MG132-mediated activation of caspase-3. Inhibited the H2O2-mediated activation of caspase-3. Inhibited caspase-3 activity in a tTG-independent manner.

Cystamine (oral, i.p.; 112, 225 mg/kg) reduces Tgase activity and GGEL levels, lessens the behavioral and neuropathological severity, and extends survival in R6/2 transgenic HD mice.Animal Model:R6/2 transgenic HD mice Dosage:112, 225 mg/kg Administration:Intraperitoneal or oral, dailyResult:Significantly extended survival, improved body weight and motor performance, delayed the neuropathological sequela and significantly altered the levels of Tgase activity and N(Sigma)-(gamma-L-glutamyl)-L-lysine (GGEL) levels.

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Apoptosis

Caspase

Caspase

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51-85-4

152.28

C4H12N2S2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (656.69 mM; Ultrasonic ) H2O : 100 mg/mL (656.69 mM; Ultrasonic)

NCCSSCCN

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(-20℃)

With Ice Pack

≥ 2 years