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Chelidonic acid
CAS No. 99-32-1
Chelidonic acid( Jerva acid | Jervaic acid | γ-Pyrone-26-dicarboxylic acid )
Catalog No. M20309 CAS No. 99-32-1
Chelidonic acid is a component of Chelidonium majus L. used as a mild analgesic an antimicrobial an acentral nervous system sedative. Chelidonic acid also shows anti-inflammatory activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
|
| 100MG | 27 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameChelidonic acid
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NoteResearch use only, not for human use.
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Brief DescriptionChelidonic acid is a component of Chelidonium majus L. used as a mild analgesic an antimicrobial an acentral nervous system sedative. Chelidonic acid also shows anti-inflammatory activity.
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DescriptionChelidonic acid is a component of Chelidonium majus L. used as a mild analgesic an antimicrobial an acentral nervous system sedative. Chelidonic acid also shows anti-inflammatory activity.
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In VitroChelidonic acid dose-dependently decreases IL-6 production at 0.1-10 μM, inhibits expression of IL-6 mRNA at 1-10 μM.Chelidonic acid (0.1-10 μM) decreases caspase-1 activation, nuclear NF-κB activation, and increases cytosol NF-κB activation.Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM. Chelidonic acid does not promote formation of apoenzyme or react with free pyridoxal-P.
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In VivoChelidonic acid (0.2, 2 mg/kg p.o.) attenuates allergic reaction induced by ovalbumin in mice.
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SynonymsJerva acid | Jervaic acid | γ-Pyrone-26-dicarboxylic acid
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PathwayApoptosis
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TargetCaspase
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RecptorCaspase-1|NF-κB
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Research Area——
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Indication——
Chemical Information
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CAS Number99-32-1
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Formula Weight184.1
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Molecular FormulaC7H4O6
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Purity>98% (HPLC)
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SolubilityDMSO:4 mg/mL (21.72 mM)
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SMILESOC(=O)c1cc(=O)cc(o1)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Singh D K Gulati K Ray A . Effects of chelidonic acid a secondary plant metabolite on mast cell degranulation and adaptive immunity in rats[J]. International Immunopharmacology 2016 40:229-234.
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