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Home - Products - Metabolic Enzyme/Protease - Phospholipase - Compound 48/80 trihydrochloride

Compound 48/80 trihydrochloride

CAS No. 848035-21-2

Compound 48/80 trihydrochloride( —— )

Catalog No. M33209 CAS No. 848035-21-2

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of N-methyl-p-methoxyphenethylamine and formaldehyde produced via a condensation reaction.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Compound 48/80 trihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of N-methyl-p-methoxyphenethylamine and formaldehyde produced via a condensation reaction.
  • Description
    Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets .
  • In Vitro
    ——
  • In Vivo
    Animal Model:7-week-old Wistar male rats (fasted for 24 hours) Dosage:0.75 mg/kg Administration:Intraperitoneal injection; Killed after 0.5, 3 or 6 h Result:Serum histamine and serotonin concentrations significantly higher than those in untreated control rats at 0.5 h after treatment. The increased serum histamine and serotonin concentrations in rats decreased time-dependently thereafter.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phospholipase
  • Recptor
    Phospholipase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    848035-21-2
  • Formula Weight
    629.1
  • Molecular Formula
    C32H48Cl3N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 25 mg/mL (39.74 mM; Ultrasonic) DMSO : 10 mg/mL (15.90 mM; Ultrasonic (<60°C)
  • SMILES
    Cl.Cl.Cl.CNCCc1ccc(OC)c(Cc2cc(CCNC)cc(Cc3cc(CCNC)ccc3OC)c2OC)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bronner C, et al. Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet. Biochim Biophys Acta. 1987 Aug 15;920(3):301-5.?
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