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SJB3-019A B

CAS No. 2070015-29-9

SJB3-019A B( —— )

Catalog No. M33125 CAS No. 2070015-29-9

SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 times more than SJB2-043, with IC50 of 0.0781 μM. SJB3-019A inhibits cell proliferation and causes cell apoptosis.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    SJB3-019A B
  • Note
    Research use only, not for human use.
  • Brief Description
    SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 times more than SJB2-043, with IC50 of 0.0781 μM. SJB3-019A inhibits cell proliferation and causes cell apoptosis.
  • Description
    SJB3-019A is a potent and novel USP1 inhibitor, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells with IC50 of 0.0781 μM.
  • In Vitro
    SJB3-019A (IC50=0.0781 μM) is 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells. SJB3-019A increases the levels of Ub-FANCD2 and Ub-PCNA, and decreases the HR activity.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    DUB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2070015-29-9
  • Formula Weight
    276.25
  • Molecular Formula
    C16H8N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 10 mg/mL (36.20 mM; Ultrasonic )
  • SMILES
    O=C1c2nc(oc2C(=O)c2ccccc12)-c1cccnc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Helena Mistry, et al. Small molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther Published OnlineFirst October 15, 2013.?
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