XL177A( —— )

Catalog No. M24114 CAS No. 2417089-74-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

XL177A
Note

Research use only, not for human use.
Brief Description

XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.
Description

XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.
In Vitro

Western Blot Analysis Cell Line:MCF7 cells Concentration:0.001, 0.01, 0.1, 1, 10 μM Incubation Time:18-24 hours Result:The p53 and p21 protein levels remained high, but MDM2 protein levels matched DMSO control.
In Vivo

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Synonyms

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Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

USP7
Research Area

——
Indication

——

CAS Number

2417089-74-6
Formula Weight

861.47
Molecular Formula

C48H57ClN8O5
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 25 mg/mL (29.02 mM)
SMILES

O=C(NC1=CC(N=CN2CC3(O)CCN(C([C@H](CC4=CC=CC=C4)CCCNC(C5=CC(N=C(CCCC6)C6=C7Cl)=C7C=C5)=O)=O)CC3)=C(C=C1)C2=O)CCN8CCN(C)CC8
Chemical Name

——

1.Nathan J Schauer, et al. Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism. Sci Rep.2020 Mar 24;10(1):5324.

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