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MLS000544460
CAS No. 352336-36-8
MLS000544460( —— )
Catalog No. M33030 CAS No. 352336-36-8
MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor (Kd: 2.0 μM, IC50: 4 μM) that exhibits inhibitory effects on Eya2 phosphatase-mediated cell migration and has anticancer activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 90 | In Stock |
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| 5MG | 79 | In Stock |
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| 10MG | 125 | In Stock |
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| 25MG | 215 | In Stock |
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| 50MG | 291 | In Stock |
|
| 100MG | 418 | In Stock |
|
| 200MG | 565 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMLS000544460
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NoteResearch use only, not for human use.
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Brief DescriptionMLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor (Kd: 2.0 μM, IC50: 4 μM) that exhibits inhibitory effects on Eya2 phosphatase-mediated cell migration and has anticancer activity.
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DescriptionMLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with a Kd of 2.0 μM and an IC50 of 4 μM. MLS000544460 inhibit Eya2 phosphatase mediated cell migration and has anti-cancer activity.
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In VitroMLS000544460 does not bind Eya3 phosphatase (ED). MLS000544460 (10 μM) inhibits Eya2-mediated cell migration in human Eya2, Eya2 phosphatase-dead (D274N), and YFP (as a negative control) expressing MCF10A cells. When Eya2 ED is dialyzed into 10 μM EDTA to remove Mg2+, it binds MLS000544460 with a higher affinity (Kd=0.80 μM), indicating that this class of compounds does not require Mg2+ for its interaction with the Eya2 ED.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPhosphatase
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RecptorPhosphatase
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Research Area——
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Indication——
Chemical Information
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CAS Number352336-36-8
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Formula Weight341.36
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Molecular FormulaC17H12FN3O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (366.18 mM; Ultrasonic )
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SMILESFc1cccc(c1)C(=O)N\N=C\c1ccc(Sc2ccccn2)o1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Krueger AB, et al. Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cellmigration. J Biol Chem. 2014 Jun 6;289(23):16349-61.?
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