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E64FC26

CAS No. 2285446-62-8

E64FC26( —— )

Catalog No. M32900 CAS No. 2285446-62-8

E64FC26 is a potent protein disulfide isomerase (PDI) family pan-inhibitor with antitumor activity, inhibits PDIA1, PDIA3, PDIA4, TXNDC5 and PDIA6, and can be used in the study of multiple myeloma and pancreatic cancer.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    E64FC26
  • Note
    Research use only, not for human use.
  • Brief Description
    E64FC26 is a potent protein disulfide isomerase (PDI) family pan-inhibitor with antitumor activity, inhibits PDIA1, PDIA3, PDIA4, TXNDC5 and PDIA6, and can be used in the study of multiple myeloma and pancreatic cancer.
  • Description
    E64FC26 is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6, respectively. E64FC26 shows anti-myeloma activity.
  • In Vitro
    Cell Viability Assay Cell Line:MM.1S BzR cells Concentration:0.01, 0.1, 1, 10, 100 μM Incubation Time:24 hours Result:Showed anti-MM activity , with an EC50 of 0.59 μM.
  • In Vivo
    Animal Model:NOD-SCID IL2Rγ-/- (NSG) mice (bearing MM.1S cells) Dosage:2 mg/ kg Administration:i.p.; three days a week for 7days Result:Showed a clear anti-MM effect in this model also, increasing median survival by 2 weeks.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2285446-62-8
  • Formula Weight
    340.38
  • Molecular Formula
    C19H23F3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (293.79 mM; Ultrasonic )
  • SMILES
    C(F)(F)(F)C=1C=2C(\C(=C\CCCCCCCC)\C1)=CC(O)=C(O)C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Robinson RM, et al. Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma. Leukemia. 2019 Apr;33(4):1011-1022.?
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