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GS-143

CAS No. 916232-21-8

GS-143( GS 143 | GS143 )

Catalog No. M24964 CAS No. 916232-21-8

GS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 52 In Stock
2MG 30 In Stock
5MG 50 In Stock
10MG 80 In Stock
25MG 164 In Stock
50MG 254 In Stock
100MG 369 In Stock
200MG 537 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    GS-143
  • Note
    Research use only, not for human use.
  • Brief Description
    GS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation.
  • Description
    GS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup-presses NF-κB acti-va-tion and tran-scrip-tion of tar-get genes and does not inhibit proteasome activity. GS143 has anti-asthma effect.
  • In Vitro
    ——
  • In Vivo
    Animal Model:BALB/c mice (age 7-8weeks) injected with oval-bu-min Dosage:16 μg/body or 32 μg/body Administration:Intranasal administration; once Result:Suppressed antigen-induced NF-κB activation in the lung of sensitized mice.
  • Synonyms
    GS 143 | GS143
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    IκBα?phosphorylation
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    916232-21-8
  • Formula Weight
    466.46
  • Molecular Formula
    C28H19FN2O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:40 mg/mL?(85.75 mM;?Need ultrasonic)
  • SMILES
    OC(c(cc1)ccc1N(C1=O)N=C(Cc2ccccc2)C1=Cc1ccc(-c(cccc2)c2F)o1)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Rashmi BS, Gayathri D. Molecular characterization of gluten hydrolysing Bacillus sp. and their efficacy and biotherapeutic potential as probiotics using Caco-2 cell line. J Appl Microbiol. 2017 Sep;123(3):759-772. doi: 10.1111/jam.13517. Epub 2017 Aug 4. PubMed PMID: 28637081.
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