Nicotredole

Research use only, not for human use.

Nicotredole (Tryptamide) is an orally active anti-inflammatory and analgesic agent. Nicotredole exhibits evident antiinflammatory effects of potency comparable with Phenylbutazone. Nicotredole has only weak ulcerogenic activity.

Nicotredole (Tryptamide) is an orally active anti-inflammatory and analgesic agent. Nicotredole exhibits evident antiinflammatory effects of potency comparable with Phenylbutazone. Nicotredole has only weak ulcerogenic activity.(In Vitro):Nicotredole inhibits prostaglandin synthetase activity in vitro . (In Vivo):Nicotredole produces antiinflammatory effects in carrageenin-induced rat paw oedema . Nicotredole reverses pyrogen-induced hyperthermia in rats, elicits analgesic effects in rats, prolongs the time of hexobarbital sleep in rats and inhibits locomotor activity in rats and mice . Nicotredole (i.p.) has LD50s of 1260 mg/kg and 1980 mg/kg for male rats and male mice, respectively . Nicotredole (p.o.) has LD50s of 8.5 g/kg and 9.3 g/kg for male rats and male mice, respectively . Nicotredole (25 mg/kg; p.o. or i.p.) undergoes fast absorption (t 1/2 =4.92-17.5 min) and elimination (t 1/2 =55.72-74.52 min), can reach C max (11-13 μg/cm 3 ) after 30 min, and gives AUC values in the range of 21.40-27.30 (μgh/cm 3 ) .

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Tryptamide

Others

Other Targets

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29876-14-0

265.316

C16H15N3O

>98% (HPLC)

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O=C(NCCc1c[nH]c2ccccc12)c1cccnc1

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(-20℃)

With Ice Pack

≥ 2 years