Coumetarol

Research use only, not for human use.

Coumetarol (Dicumoxane) is a vitamin K antagonist and an oral anticoagulant that can be used to study arterial thrombotic occlusion.

Coumetarol (Dicumoxane) is a vitamin K antagonist.

Coumetarol (Dicumoxane), an oral anticoagulant, is active in both models. The vitamin K antagonist Coumetarol is effective in both models after oral treatment but inhibits the thrombus formation more strongly in the arterio-venous shunt model. Treatment with the vitamin K antagonist Coumetarol in a dose of 25 mg/kg p.o. twice daily for 2 days results in a significant reduction in thrombus weight by 50% in the venous stasis model and by 75% in the arterio-venous shunt model. In both experiments the coagulation time as measured by the Thrombotest is prolonged to the same extent.

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Metabolic Enzyme/Protease

Vitamin

Vitamin

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4366-18-1

380.35

C21H16O7

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (657.29 mM; Ultrasonic )

O=C1OC=2C=CC=CC2C(O)=C1C(C=3C(=O)OC=4C=CC=CC4C3O)COC

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(-20℃)

With Ice Pack

≥ 2 years