Beta-Carotene

Research use only, not for human use.

β-Carotene is an organic compound and classified as a terpenoid. It is a precursor (inactive form) of vitamin A.

β-Carotene is an organic compound and classified as a terpenoid. It is a precursor (inactive form) of vitamin A.(In Vitro):β-Carotene up-regulates PPAR-γ expression and ROS production in MCF-7 cancer cells.β-Carotene (1-100 μM; 72 hours) remarkably decreases the survival of MCF-7 cells in a dose-dependent manner.β-Carotene (50 μM; 24-72 hours) significantly enhances the expression levels of PPAR-γ mRNA and protein in a time-dependent manner.β-Carotene down-regulates the COX-2 but up-regulates the p21 mRNA level and protein expression in a time dependent manner.β-Carotene significantly increases the percentage of early apoptosis and the effect was partly attenuated by pre-incubation with GW9662 (HY-16578) or GSH (HY-D0187).β-Carotene induces cytochrome C release.

β-Carotene up-regulates PPAR-γ expression and ROS production in MCF-7 cancer cells.β-Carotene (1-100 μM; 72 hours) remarkably decreases the survival of MCF-7 cells in a dose-dependent manner.β-Carotene (50 μM; 24-72 hours) significantly enhances the expression levels of PPAR-γ mRNA and protein in a time-dependent manner.β-Carotene down-regulates the COX-2 but up-regulates the p21 mRNA level and protein expression in a time dependent manner.β-Carotene significantly increases the percentage of early apoptosis and the effect was partly attenuated by pre-incubation with GW9662 (HY-16578) or GSH (HY-D0187).β-Carotene induces cytochrome C release. Cell Viability Assay Cell Line:MCF-7 cells Concentration:1 μM, 10 μM, 20 μM, 50 μM, 100 μM Incubation Time:72 hours Result:Decreased the numbers of viable cells to 70% and 50% at 20 μMand 50 μM, respectively.RT-PCR Cell Line:MCF-7 cells Concentration:50 μM Incubation Time:24 hours, 48 hours, 72 hours Result:Up-regulated the PPAR-γ mRNA.Western Blot Analysis Cell Line:MCF-7 cells Concentration:50 μM Incubation Time:24 hours, 48 hours, 72 hours Result:Up-regulated PPAR-γ protein expression levels.Apoptosis Analysis Cell Line:MCF-7 cells Concentration:50 μM Incubation Time:72 hours Result:Induced MCF-7 cells apoptosis.

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Food Orange 5 | KPMK | Lucarotin | NSC 62794 | Provatene | Provitamin A | Solatene

Metabolic Enzyme/Protease

Vitamin

VA

Metabolic Disease

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7235-40-7

536.87

C40H56

>98% (HPLC)

Ethanol: 5 mg/mL warmed (9.31 mM); DMSO: 4 mg/mL warmed (7.45 mM)

CC(/C=C/C1=C(C)CCCC1(C)C)=C\C=C\C(C)=C\C=C\C=C(C)\C=C\C=C(C)\C=C\C2=C(C)CCCC2(C)C

(all-E)-1,1'-(3,7,12,16-Tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis(2,6,6-trimethylcyclohexene)

(-20℃)

With Ice Pack

≥ 2 years