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Home - Products - Cell Cycle/DNA Damage - CDK - CDK8-IN-1

CDK8-IN-1

CAS No. 1629633-48-2

CDK8-IN-1( —— )

Catalog No. M32834 CAS No. 1629633-48-2

CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 240 In Stock
5MG 217 In Stock
10MG 312 In Stock
25MG 525 In Stock
50MG 693 In Stock
100MG 923 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    CDK8-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).
  • Description
    CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.
  • In Vitro
    ——
  • In Vivo
    CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The tmax is 0.25 h by PO. The mean values of Cmax are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    CDK
  • Recptor
    CDK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1629633-48-2
  • Formula Weight
    255.2
  • Molecular Formula
    C11H8F3N3O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (391.85 mM; Ultrasonic )
  • SMILES
    NC(=O)c1[nH]cc(c1C(F)(F)F)-c1ccncc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Han X, et al. Discovery of potent and selective CDK8 inhibitors through FBDD approach. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4488-4492.?
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