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CDK8-IN-1
CAS No. 1629633-48-2
CDK8-IN-1( —— )
Catalog No. M32834 CAS No. 1629633-48-2
CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 240 | In Stock |
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| 5MG | 217 | In Stock |
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| 10MG | 312 | In Stock |
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| 25MG | 525 | In Stock |
|
| 50MG | 693 | In Stock |
|
| 100MG | 923 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCDK8-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionCDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).
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DescriptionCDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.
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In Vitro——
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In VivoCDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The tmax is 0.25 h by PO. The mean values of Cmax are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number1629633-48-2
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Formula Weight255.2
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Molecular FormulaC11H8F3N3O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (391.85 mM; Ultrasonic )
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SMILESNC(=O)c1[nH]cc(c1C(F)(F)F)-c1ccncc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Han X, et al. Discovery of potent and selective CDK8 inhibitors through FBDD approach. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4488-4492.?
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