Home - Products - Cell Cycle/DNA Damage - CDK - CDK8-IN-1

CDK8-IN-1

CAS No. 1629633-48-2

CDK8-IN-1( —— )

Catalog No. M32834 CAS No. 1629633-48-2

CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	240	In Stock
5MG	217	In Stock
10MG	312	In Stock
25MG	525	In Stock
50MG	693	In Stock
100MG	923	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

Get Quotation Bulk Inquiry Add to Cart

Biological Information

Product Name

CDK8-IN-1
Note

Research use only, not for human use.
Brief Description

CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).
Description

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.
In Vitro

——
In Vivo

CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The tmax is 0.25 h by PO. The mean values of Cmax are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively.
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

CDK
Recptor

CDK
Research Area

——
Indication

——

Chemical Information

CAS Number

1629633-48-2
Formula Weight

255.2
Molecular Formula

C11H8F3N3O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (391.85 mM; Ultrasonic )
SMILES

NC(=O)c1[nH]cc(c1C(F)(F)F)-c1ccncc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Han X, et al. Discovery of potent and selective CDK8 inhibitors through FBDD approach. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4488-4492.?

Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog

related products

Dinaciclib

A potent and selective CDK inhibitor with IC50 of 1, 1, 3 and 4 nM against CDK2, CDK5, CDK1 and CDK9, respectively.
WAY-322243

WAY-322243 has antibacterial and anti-inflammatory activity and has an inhibitory effect on CLK-1, which can be used to study Alzheimer's disease.
XPW1

XPW1 is a new potent and selective CDK9 inhibitor with antitumour activity that transcriptionally inhibits the DNA repair process in ccRCC cells.XPW1 can be used to study clear cell renal cell carcinoma.

Sign In Join Free