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Home - Products - Cell Cycle/DNA Damage - CDK - CDK8-IN-1

CDK8-IN-1

CAS No. 1629633-48-2

CDK8-IN-1( —— )

Catalog No. M32834 CAS No. 1629633-48-2

CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 135 Get Quote
5MG 217 Get Quote
10MG 312 Get Quote
25MG 509 Get Quote
50MG 685 Get Quote
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Biological Information

  • Product Name
    CDK8-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).
  • Description
    CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.
  • In Vitro
    ——
  • In Vivo
    CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The tmax is 0.25 h by PO. The mean values of Cmax are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    CDK
  • Recptor
    CDK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1629633-48-2
  • Formula Weight
    255.2
  • Molecular Formula
    C11H8F3N3O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (391.85 mM; Ultrasonic )
  • SMILES
    NC(=O)c1[nH]cc(c1C(F)(F)F)-c1ccncc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Han X, et al. Discovery of potent and selective CDK8 inhibitors through FBDD approach. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4488-4492.?
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