CDK9-IN-7

Research use only, not for human use.

CDK9-IN-7 is a highly selective and orally active CDK9/cyclin T inhibitor (IC50: 11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD: 148 nM; CDK6/cyclinD: 145 nM).

CDK9-IN-7 (compound 21e) is a selective, highly potent, and orally active CDK9/cyclin T inhibitor (IC50=11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD=148 nM; CDK6/cyclinD=145 nM). CDK9-IN-7 shows antitumor activity without obvious toxicity. CDK9-IN-7 induces NSCLC cell apoptosis, arrests the cell cycle in the G2 phase, and suppresses the stemness properties of NSCLC.

CDK9-IN-7 displays exceptional potency against NSCLC cell lines, especial A549 and H1299 with IC50 values less than 0.5 μM. In the drug-resistant NSCLC cell line H1975, CDK9-IN-7 also exhibits good inhibition potency with an IC50 value of 0.837 μM.

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Cell Cycle/DNA Damage

CDK

CDK

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2369981-71-3

547.71

C29H37N7O2S

>98% (HPLC)

In Vitro:?DMSO : 62.5 mg/mL (114.11 mM; Ultrasonic )

C(N(C)C)(=O)C=1N(C=2C(C1)=CN=C(NC3=CC=C(NC(CCCCCCCN=C=S)=O)C=C3)N2)C4CCCC4

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(-20℃)

With Ice Pack

≥ 2 years